Friday, February 5, 2016

#HIV: CDC Report on Disparities in Consistent Retention in HIV Care

Disparities in Consistent Retention in HIV Care - 11 States and the District of Columbia, 2011–2013


*This is the full report on retention in HIV care care released yesterday by the CDC in its Morbidity and Mortality Weekly Report (MMWR)*

In 2013, 45% of new human immunodeficiency virus (HIV) infection diagnoses occurred in non-Hispanic blacks/African Americans (blacks) (1), who represent 12% of the U.S. population.* Antiretroviral therapy (ART) improves clinical outcomes and reduces transmission of HIV, which causes acquired immunodeficiency syndrome (AIDS) (2). Racial/ethnic disparities in HIV care limit access to ART, perpetuating disparities in survival and reduced HIV transmission. National HIV Surveillance System (NHSS) data are used to monitor progress toward reaching the National HIV/AIDS Strategy goals to improve care among persons living with HIV and to reduce HIV-related disparities.† CDC used NHSS data to describe retention in HIV care over 3 years and describe differences by race/ethnicity. Among persons with HIV infection diagnosed in 2010 who were alive in December 2013, 38% of blacks with HIV infection were consistently retained in care during 2011–2013, compared with 50% of Hispanics/Latinos (Hispanics) and 49% of non-Hispanic whites (whites). Differences in consistent retention in care by race/ethnicity persisted when groups were stratified by sex or transmission category. Among blacks, 35% of males were consistently retained in care compared with 44% of females. Differences in HIV care retention by race/ethnicity were established during the first year after diagnosis. Efforts to establish early HIV care among blacks are needed to mitigate racial/ethnic disparities in HIV outcomes over time.

All states and U.S. territories report cases of HIV infections and associated demographic and clinical information to NHSS. CDC analyzed data from NHSS reported through July 2015 from 12 jurisdictions with complete laboratory reporting from January 2010–December 2013.§ These jurisdictions accounted for 25% of HIV diagnoses reported in the United States for 2010. This analysis includes persons aged ≥13 years who received a diagnosis of HIV infection in 2010 and were alive in December 2013. Retention in HIV care, defined as having two or more CD4+ or viral load tests ≥3 months apart during a given calendar year, was assessed annually for 2011, 2012, and 2013. The percentage of persons retained in care for 0, 1, 2, and 3 years during 2011–2013 was determined. Persons retained in care for all 3 years were considered to be consistently retained in HIV care. Differences in consistent retention in care were assessed by race/ethnicity, sex, transmission category, and state of residence at diagnosis. Results were statistically adjusted for missing information on transmission category using multiple imputation (3).

In the 12 jurisdictions, a total of 9,824 adults and adolescents received a diagnosis of HIV infection in 2010 and were alive in December 2013. Of the 9,824, 54% were black, 17% were Hispanic, and 24% were white. Overall, 61% were retained in HIV care in 2011, 50% were retained in both 2011 and 2012, and 43% were retained during 2011–2013 (Figure 1). Among persons retained in care in 2011, 82% were retained in both 2011 and 2012. Among persons retained in care during both 2011 and 2012, 85% were retained during 2011–2013. A lower proportion of blacks were retained during 2011–2013 (38%), compared with Hispanics (50%) and whites (49%).
FIGURE 1Percentage of persons aged ≥13 years with human immunodeficiency virus (HIV) infection diagnosed in 2010 who were alive in December 2013 and who were retained in HIV medical care* during 2011–2013, by race/ethnicity and years retained in care — National HIV Surveillance System, 11 states and the District of Columbia†
The figure above is a bar chart showing the percentage of persons aged ≥13 years with HIV infection diagnosed in 2010 who were alive in December 2013 and who were retained in HIV medical care during 2011–2013, by race/ethnicity and years retained in care.

*Retention in HIV care was defined as having two or more CD4+ or viral load tests ≥3 months apart during a given calendar year and was assessed annually for 2011, 2012, and 2013.

† Only jurisdictions with complete laboratory reporting were included in the analysis: District of Columbia, Illinois, Indiana, Iowa, Louisiana, Michigan, Missouri, New Hampshire, New York, North Dakota, South Carolina, and West Virginia.

Differences in consistent retention in care by race/ethnicity persisted when stratified by sex or transmission category, with a lower proportion of blacks retained in HIV care for all 3 years, compared with other groups (Table). Further, retention in care for all 3 years was lower among blacks in seven of the 12 jurisdictions (District of Columbia, Illinois, Iowa, Michigan, Missouri, New Hampshire, and New York).
TABLEConsistent retention* in human immunodeficiency virus (HIV) medical care among persons aged ≥13 years with HIV infection diagnosed in 2010 who were alive in December 2013, by race/ethnicity and selected characteristics — National HIV Surveillance System, 11 states and the District of Columbia
CharacteristicRace/Ethnicity
OverallBlack/African AmericanHispanic/LatinoWhite
TotalConsistently retainedTotalConsistently retainedTotalConsistently retainedTotalConsistently retained
No. (%)No. (%)No. (%)No. (%)No. (%)No. (%)No. (%)No. (%)
Total9,824 (100.0)4,201 (42.8)5,286 (100.0)1,993 (37.7)1,682 (100.0)833 (49.5)2,358 (100.0)1,145 (48.6)
Sex
Male7,566 (77.0)3,173 (41.9)3,712 (70.2)1,297 (34.9)1,356 (80.6)673 (49.6)2,094 (88.8)1,024 (48.9)
Female2,258 (23.0)1,028 (45.5)1,574 (29.8)696 (44.2)326 (19.4)160 (49.1)264 (11.2)121 (45.8)
Transmission category
Male-to-male sexual contact5,953 (60.6)2,530 (42.5)2,732 (51.7)956 (35.0)1,056 (62.8)526 (49.8)1,844 (78.2)903 (49.0)
Male-to-male sexual contact and injection drug use285 (2.9)110 (38.6)111 (2.1)29 (26.3)50 (3.0)22 (44.0)103 (4.4)51 (49.8)
Injection drug use, males474 (4.8)181 (38.2)279 (5.3)91 (32.6)114 (6.8)53 (46.5)66 (2.8)30 (45.5)
Injection drug use, females332 (3.4)146 (44.0)210 (4.0)85 (40.5)43 (2.6)24 (55.8)67 (2.8)28 (41.8)
Heterosexual contact, males843 (8.6)348 (41.3)584 (11.0)218 (37.3)134 (8.0)71 (53.0)78 (3.3)39 (50.0)
Heterosexual contact, females1,918 (19.5)879 (45.8)1,359 (25.7)610 (44.9)282 (16.8)135 (47.9)197 (8.4)92 (46.7)
Other20 (0.2)7 (35)12 (0.2)4 (33.3)3 (0.2)2 (66.7)3 (0.1)1 (33.3)
Jurisdiction
District of Columbia794 (8.1)278 (35.0)620 (11.7)207 (33.4)52 (3.1)22 (42.3)103 (4.4)46 (44.7)
Illinois1,570 (16.0)421 (26.8)806 (15.2)179 (22.2)280 (16.6)99 (35.4)372 (15.8)102 (27.4)
Indiana444 (4.5)184 (41.4)200 (3.8)76 (38.0)40 (2.4)14 (35.0)185 (7.8)87 (47.0)
Iowa102 (1.0)51 (50.0)23 (0.4)10 (43.5)10 (0.6)5 (50.0)60 (2.5)32 (53.3)
Louisiana1,027 (10.5)387 (37.7)755 (14.3)262 (34.7)36 (2.1)10 (27.8)210 (8.9)107 (51.0)
Michigan723 (7.4)292 (40.4)438 (8.3)152 (34.7)43 (2.6)19 (44.2)216 (9.2)109 (50.5)
Missouri543 (5.5)193 (35.5)272 (5.1)68 (25.0)29 (1.7)11 (37.9)221 (9.4)104 (47.1)
New Hampshire50 (0.5)30 (60.0)2 (0.0)1 (50.0)3 (0.2)2 (66.7)40 (1.7)24 (60.0)
New York3,759 (38.3)1,997 (53.1)1,613 (30.5)788 (48.9)1,147 (68.2)640 (55.8)756 (32.1)435 (57.5)
North Dakota12 (0.1)6 (50.0)3 (0.1)1 (33.3)3 (0.2)1 (33.3)5 (0.2)4 (80.0)
South Carolina725 (7.4)343 (47.3)542 (10.3)245 (45.2)33 (2.0)10 (30.3)136 (5.8)80 (58.8)
West Virginia75 (0.8)19 (25.3)12 (0.2)4 (33.3)6 (0.4)0 (0.0)54 (2.3)15 (27.8)
*Defined as retained in HIV care each year during 2011–2013. Retention in HIV care was defined as having two or more CD4+ or viral load tests ≥3 months apart during a given calendar year.
† Because the estimated totals were calculated independently of the corresponding values for each population group, the individual values might not sum to the totals.

A smaller percentage of black males, who accounted for more than two thirds of blacks with HIV diagnosed in 2010, were consistently retained in care during 2011–2013 compared with black females (35% versus 44%, respectively) (Table). Among blacks, consistent retention in care was highest for persons with infection attributable to heterosexual contact, and among these persons, consistent retention in care was higher for females (45%) than for males (37%).

Overall, 43% of all persons included in the analysis were retained in HIV care for all 3 years during 2011–2013. Nineteen percent were retained 2 of the 3 years; 14% were retained 1 of the 3 years, and 25% were not retained in any of the 3 years (Figure 2). A larger proportion of blacks (28%), compared with Hispanics (23%) and whites (19%), were not retained in care during any of the 3 years.
FIGURE 2Percentage of persons aged ≥13 years with human immunodeficiency virus (HIV) infection diagnosed in 2010 who were alive in December 2013 and who were retained in HIV medical care* for 0, 1, 2, or 3 out of 3 years, by race/ethnicity — National HIV Surveillance System, 11 states and the District of Columbia†
The figure above is a bar chart showing the percentage of persons aged ≥13 years with HIV infection diagnosed in 2010 who were alive in December 2013 and who were retained in HIV medical care for 0, 1, 2, or 3 out of 3 years, by race/ethnicity.
*Retention in HIV care was defined as having two or more CD4+ or viral load tests ≥3 months apart during a given calendar year and was assessed annually for 2011, 2012, and 2013.
 Only jurisdictions with complete laboratory reporting were included in the analysis: District of Columbia, Illinois, Indiana, Iowa, Louisiana, Michigan, Missouri, New Hampshire, New York, North Dakota, South Carolina, and West Virginia.

Discussion


A substantial percentage of persons with HIV infection (39%) were not retained in care in the year after their diagnosis. However, among persons retained during earlier years after diagnosis, the proportion not retained during subsequent years was low (18% in 2012 and 15% in 2013, respectively). Fewer blacks were retained in HIV care compared with other racial/ethnic groups. These findings are consistent with previous reports on racial/ethnic differences in HIV care engagement (4) and demonstrate that these disparities remain over multiple years. The racial/ethnic differences in HIV care retention are established during the first year after diagnosis, underscoring the importance of early engagement in care to reduce disparities in sustained retention in care and thus improve the resulting outcomes (e.g., initiation of treatment and viral suppression).

Retention in care facilitates ART adherence and early detection of comorbidities, which can result in improved survival and reduced transmission of infection to others (2,5). Barriers to retention in care, such as lack of health insurance, limited access to health services, and stigma, are particularly prevalent among blacks (6). Continuing to identify barriers to HIV care engagement, including those leading to prolonged lack of retention in care, can inform development of effective interventions to improve HIV care engagement among blacks (7). Developing such interventions might narrow racial/ethnic disparities in clinical outcomes.

The findings in this report are subject to at least four limitations. First, HIV surveillance data do not include markers of socioeconomic status (e.g., health insurance status, annual household income, or education), which could help explain observed disparities in HIV care engagement by racial/ethnic groups. Second, analyses were restricted to 12 jurisdictions with complete laboratory reporting during the entire analysis period; these 12 jurisdictions might not be representative of all persons living with diagnosed HIV infection. Third, this analysis was limited to persons with HIV infection diagnosed during a 1-year period; for this reason, estimates are different from those previously published (4). Finally, these multiyear estimates of retention in HIV care might be artificially lower if persons moved to a jurisdiction with incomplete laboratory reporting after receiving an HIV diagnosis; however, a previous analysis of HIV surveillance data concluded that interstate migration is relatively uncommon.¶

Focusing HIV prevention and care efforts on early diagnosis of HIV infection and early establishment of HIV care among blacks might be beneficial in reducing racial/ethnic disparities in HIV outcomes. Through partnerships with federal, state, and local health agencies, CDC is pursuing high-impact prevention strategies to address the principal goals of the National HIV/AIDS Strategy to increase access to care and reduce disparities in HIV outcomes.** CDC supports projects that aim to reduce the proportion of undiagnosed infections in the United States, improve linkage to and retention in care, and reduce HIV-related morbidity and mortality across all racial/ethnic groups (8). CDC also supports using surveillance data to 1) identify persons who are not currently in care, 2) improve HIV care engagement, and 3) increase viral suppression (9). Continued collaboration among health care providers, community-based organizations, and state and local health departments can strengthen programs that support both early linkage to care after HIV diagnosis across all racial/ethnic groups and expansion of proven methods for improving retention in care (e.g., HIV case management, patient navigation systems, and co-location of medical services) (7,10).

For PDF of report: http://www.cdc.gov/mmwr/volumes/65/wr/pdfs/mm6504.pdf

Corresponding author: Sharoda Dasgupta, sdasgupta@cdc.gov, 404-639-5191.

1Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, CDC; 2Epidemic Intelligence Service, CDC.

References

  1. CDC. HIV surveillance report: diagnoses of HIV infection in the United States and dependent areas, 2013. Atlanta, GA: US Department of Health and Human Services, CDC; 2015.http://www.cdc.gov/hiv/library/reports/surveillance/.
  2. Mugavero MJ, Amico KR, Westfall AO, et al. Early retention in HIV care and viral load suppression: implications for a test and treat approach to HIV prevention. J Acquir Immune Defic Syndr 2012;59:86–93.  CrossRef PubMed
  3. Harrison KM, Kajese T, Hall HI, Song R. Risk factor redistribution of the national HIV/AIDS surveillance data: an alternative approach. Public Health Rep 2008;123:618–27. PubMed
  4. CDC. Monitoring selected national HIV prevention and care objectives by using HIV surveillance data—United States and 6 dependent areas, 2012. HIV surveillance supplemental report 2014. Vol. 19, no. 3. Atlanta, GA: US Department of Health and Human Services, CDC; 2014. http://www.cdc.gov/hiv/pdf/surveillance_Report_vol_19_no_3.pdf.
  5. Mugavero MJ, Lin HY, Willig JH, et al. Missed visits and mortality among patients establishing initial outpatient HIV treatment. Clin Infect Dis 2009;48:248–56.  CrossRef PubMed
  6. Moore RD. Epidemiology of HIV infection in the United States: implications for linkage to care. Clin Infect Dis 2011;52(Suppl 2):S208–13.  CrossRef PubMed
  7. CDC. Compendium of evidence-based interventions and best practices for HIV prevention. Atlanta, GA: US Department of Health and Human Services, CDC; 2014.http://www.cdc.gov/hiv/prevention/research/compendium/ma/index.html.
  8. CDC. The Care and Prevention in the United States (CAPUS) Demonstration Project. Atlanta, GA: US Department of Health and Human Services, CDC; 2015.http://www.cdc.gov/hiv/prevention/demonstration/capus/.
  9. CDC. Data to care: using HIV surveillance data to support the HIV care continuum. Atlanta, GA: US Department of Health and Human Services, CDC; 2015.https://effectiveinterventions.cdc.gov/en/highimpactprevention/publichealthstrategies/DatatoCare.aspx.
  10. Thompson MA, Mugavero MJ, Amico KR, et al. Guidelines for improving entry into and retention in care and antiretroviral adherence for persons with HIV: evidence-based recommendations from an International Association of Physicians in AIDS Care panel. Ann Intern Med 2012;156:817–33.  CrossRef PubMed
 Top
* U.S. Census Bureau. Population estimates. http://www.census.gov/popest/data/.
§ District of Columbia, Illinois, Indiana, Iowa, Louisiana, Michigan, Missouri, New Hampshire, New York, North Dakota, South Carolina, and West Virginia.
 Espinoza L, Hall HI, Surendera-Babu A, Tang T, Chen M. Migration after HIV diagnosis, United States. Presented at the Conference on Retroviruses and Opportunistic Infections, March 3–6, 2014, Boston, Massachusetts.

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.